Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression.

@article{Shojaei2008RoleOB,
  title={Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression.},
  author={Farbod Shojaei and Mallika Singh and Jennifer D. Thompson and Napoleone M. A. Ferrara},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 7},
  pages={2640-5}
}
The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characterized transgenic mouse model of multistage pancreatic beta-cell tumorigenesis. Also, the role of neutrophils in RIP-Tag angiogenic switching, as assessed by systemic ablation using… CONTINUE READING

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Bv 8 regulates myeloid cell - dependent tumor angiogenesis Nature

F Shojaei
2007

Cross-species VEGF-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF

WC Liang
J Biol Chem 281:951–961. Shojaei et al. PNAS February • 2006

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