Role of Brain Dynorphin in Nitrous Oxide Antinociception in Mice

@article{Branda2000RoleOB,
  title={Role of Brain Dynorphin in Nitrous Oxide Antinociception in Mice},
  author={E. M. Branda and J. Ramza and Francis J. Cahill and L. Tseng and R. Quock},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={65},
  pages={217-221}
}
Earlier studies indicate that nitrous oxide antinociception is mediated by opioid receptors, and we have hypothesized that nitrous oxide stimulates a neuronal release of an endogenous opioid peptide (EOP) that stimulates opioid receptors. To further test this hypothesis, male NIH Swiss mice were pretreated intracerebroventricularly with rabbit antisera to opioid peptides or with various inhibitors of peptidases involved in the degradation of EOPs. Mice were subsequently exposed to three… Expand
Antagonism of nitrous oxide antinociception in mice by intrathecally administered antisera to endogenous opioid peptides.
TLDR
The hypothesis that nitrous oxide antinociception in the mouse abdominal constriction test involves the neuronal release of DYN and ME in the spinal cord is supported. Expand
Antagonism of Nitrous Oxide Antinociception in Mice by Intrathecally Administered Antisera to Endogenous Opioid Peptides
Previously it was demonstrated that nitrous oxide antinociception in the mouse abdominal constriction test is mediated by κ-opioid receptors. Since nitrous oxide is thought to cause the neuronalExpand
Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain
TLDR
It is suggested that N(2)O acts in the PAG via an NO-dependent, opioid receptor-mediated mechanism to induce antinociception. Expand
Role of Nitric-Oxide Synthase Isoforms in Nitrous Oxide Antinociception in Mice
  • M. Ishikawa, R. Quock
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2003
TLDR
Results suggest that it is the neuronal isoform of NOS that is involved in mediation of the antinociceptive effect of N2O in the mice. Expand
Dynorphin-mediated antinociceptive effects of l-arginine and SIN-1 (an NO donor) in mice
TLDR
The findings indicate that the mechanisms of antinociceptive action of L-ARG and SIN-1 are both mediated by dynorphin and dependent on NO. Expand
Antagonism of the antinociceptive effect of nitrous oxide by inhibition of enzyme activity or expression of neuronal nitric oxide synthase in the mouse brain and spinal cord.
TLDR
It is consistently demonstrated that transient or developmental suppression of nNOS expression significantly reduces antinociceptive responsiveness to N(2)O, and NO of both supraspinal and spinal origin plays an important role in the antinOCiceptive response to N (2) O. Expand
Nitrous oxide-induced NO-dependent neuronal release of β-endorphin from the rat arcuate nucleus and periaqueductal gray
TLDR
Findings suggest an association between increased NO activity and the stimulated release of β-endorphin during exposure of rats to N(2)O. Expand
Neurobiology of nitrous oxide-induced antinociceptive effects
TLDR
Evidence to date indicate that N2O induces opioid peptide release in the periaqueductal gray area of the midbrain leading to the activation of the descending inhibitory pathways, which results in modulation of the pain/nociceptive processing in the spinal cord. Expand
Antagonism of phosphoramidon-induced antinociception in mice by μ- but not κ-opioid receptor blockers
Intracerebroventricular (i.c.v.) administration of the neutral endopeptidase 24.11-inhibitor phosphoramidon evoked a dose-dependent antinociceptive effect in the mouse acetic acid abdominalExpand
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
TLDR
Evidence of a persistent antinociceptive effect of hyperbaric oxygen treatment that is mediated by opioid and NO mechanisms is presented and elucidation of the underlying mechanism could identify molecular targets to cause a longer-acting activation of endogenous pain-modulating systems. Expand
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