Role of Brain Dynorphin in Nitrous Oxide Antinociception in Mice

@article{Branda2000RoleOB,
  title={Role of Brain Dynorphin in Nitrous Oxide Antinociception in Mice},
  author={Emily M Branda and Justin T. Ramza and Francis J. Cahill and Leon F. Tseng and Raymond M. Quock},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={65},
  pages={217-221}
}

Antagonism of nitrous oxide antinociception in mice by intrathecally administered antisera to endogenous opioid peptides.

The hypothesis that nitrous oxide antinociception in the mouse abdominal constriction test involves the neuronal release of DYN and ME in the spinal cord is supported.

Antagonism of Nitrous Oxide Antinociception in Mice by Intrathecally Administered Antisera to Endogenous Opioid Peptides

The hypothesis that nitrous oxide antinociception in the mouse abdominal constriction test involves the neuronal release of DYN and ME in the spinal cord is supported.

Role of Nitric-Oxide Synthase Isoforms in Nitrous Oxide Antinociception in Mice

  • M. IshikawaR. Quock
  • Biology, Chemistry
    Journal of Pharmacology and Experimental Therapeutics
  • 2003
Results suggest that it is the neuronal isoform of NOS that is involved in mediation of the antinociceptive effect of N2O in the mice.

Neurobiology of nitrous oxide-induced antinociceptive effects

Evidence to date indicate that N2O induces opioid peptide release in the periaqueductal gray area of the midbrain leading to the activation of the descending inhibitory pathways, which results in modulation of the pain/nociceptive processing in the spinal cord.

References

SHOWING 1-10 OF 27 REFERENCES

Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific mu and epsilon opioid receptor blockade.

Results indicate that supraspinal mu and epsilon opioid receptors mediate N2O antinociception in the rat hot plate paradigm and that one central site of such mu but not epsilus opioid receptors is the periaqueductal gray.

A CLASSIFICATION OF OPIATE RECEPTORS THAT MEDIATE ANTINOCICEPTION IN ANIMALS

  • M. Tyers
  • Biology
    British journal of pharmacology
  • 1980
It is concluded that both μ‐ and κ‐opiate receptors mediate antinociception in animals and that the interactions of analgesic drugs with these receptors may be classified in terms of their antinOCiceptive activities against qualitatively different nociceptive stimuli.

Nitrous oxide generalizes to a discriminative stimulus produced by ethylketocyclazocine but not morphine.

Nitrous oxide exhibits some pharmacological properties similar to those of morphine, for example, naloxone reversible analgesia, yet it has other properties such as subjective effects that are dissimilar from morphine.

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

The presence of a high-affinity peptidase in a particulate fraction of mouse striatum splitting the Leu-enkephalin molecule with release of a tripeptide fragment and exhibiting definite substrate specificity suggests that it might be associated with enkphalinergic transmission.

Tolerance to Nitrous Oxide Analgesia in Rats and Mice

The cross-tolerance between nitrous oxide and morphine appears unique in that it is unidirectional.

Dynorphin is a specific endogenous ligand of the kappa opioid receptor.

In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist ethylketocyclazocine had equally poor sensitivity to naloxone