Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

@article{Cao2005RoleOB,
  title={Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.},
  author={Ru Bo Cao and Yu-ichi Tsukada and Yi Zhang},
  journal={Molecular cell},
  year={2005},
  volume={20 6},
  pages={845-54}
}
Polycomb group (PcG) proteins exist in at least two biochemically distinct protein complexes, the EED-EZH2 complex and the PRC1 complex, that respectively possess H3-K27 methyltransferase and H2A-K119 ubiquitin E3 ligase activities. How the enzymatic activities are regulated and what their role is in Hox gene silencing are not clear. Here, we demonstrate that Bmi-1 and Ring1A, two components of the PRC1 complex, play important roles in H2A ubiquitylation and Hox gene silencing. We show that… CONTINUE READING
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