Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.

@article{Lee2008RoleOB,
  title={Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.},
  author={Dae-Hee Lee and Miroslaw J Szczepanski and Yong Joo Lee},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 12},
  pages={2345-55}
}
The aim of this study was to investigate the effect of quercetin, a flavonoid, on the apoptotic pathway in a human prostate cell line (LNCaP). We observed that treatment of cells for 24h with quercetin-induced cell death in a dose-dependent manner. A sustained inhibition of the major survival signal, Akt, occurred in quercetin-treated cells. Treatment of LNCaP cells with an apoptosis inducing concentration of quercetin (100 microM) resulted in a rapid decrease in the inhibitory Ser473… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…