Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

@article{Yoshida2004RoleOB,
  title={Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage},
  author={Kiyotsugu Yoshida and Yoshio Miki},
  journal={Cancer Science},
  year={2004},
  volume={95}
}
BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research has shown that BRCA proteins are involved in a multitude of pivotal cellular processes. In particular, both genes contribute to DNA repair and transcriptional regulation in response to DNA damage. Recent studies suggest that BRCA proteins are required for maintenance of chromosomal stability, thereby protecting the genome… 
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E ectopic expression of BRCA1 using an adenovirus vector (Ad-BRCA 1) leads to dephosphorylation of the retinoblastoma protein accompanied by a decrease in cyclin-dependent kinase activity, showing the potential to modulate the expression of genes and function of proteins involved in cell cycle control and DNA damage response pathways.
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TLDR
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TLDR
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TLDR
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TLDR
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