Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis.

@article{Minoo2007RoleOB,
  title={Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis.},
  author={Parham Minoo and Mary Pat Moyer and Jeremy R. Jass},
  journal={The Journal of pathology},
  year={2007},
  volume={212 2},
  pages={124-33}
}
There is increasing evidence for an alternative pathway of sporadic colorectal tumourigenesis that is associated with DNA microsatellite instability (MSI), due to methylation and loss of expression of the mismatch repair gene MLH1. Recent studies have highlighted a serrated pathway of colorectal cancer (CRC) in which serrated polyps with activating mutations in BRAF progress to CRCs with MSI following methylation and silencing of MLH1. The present study provides a novel mechanistic experimental… CONTINUE READING