Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency

  title={Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency},
  author={Decheng Ren and Juan Sun and Changzheng Wang and Honggang Ye and Liqun Mao and Emily H-Y Cheng and Graeme I. Bell and Kenneth S. Polonsky},
Mutations in pancreatic duodenal homeobox-1 (PDX1) are associated with diabetes in humans. Pdx1-haploinsufficient mice develop diabetes due to an increase in β-cell death leading to reduced β-cell mass. For definition of the molecular link between Pdx1 deficiency and β-cell death, Pdx1-haploinsufficient mice in which the genes for the BH3-only molecules Bim and Puma had been ablated were studied on a high-fat diet. Compared with Pdx1(+/-) mice, animals haploinsufficient for both Pdx1 and Bim or… CONTINUE READING
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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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