Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4-producing T helper cells

@article{Gause1995RoleOB,
  title={Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4-producing T helper cells},
  author={William C. Gause and Joseph F. Urban and Peter S. Linsley and Ping Lu},
  journal={Immunologic Research},
  year={1995},
  volume={14},
  pages={176-188}
}
Signaling through the T cell receptor must be accompanied by costimulatory signals for the differentiation of naive T cells to cytokine-producing effector T helper cells. The costimulatory signal through CD28 is required for T cell activation resulting in increased interleukin (IL)-2 production in vitro, but its role in the production of IL-4 and in the in vivo response is still unclear. We have examined the effects of blocking CTLA-4 (the CD28 homologue) ligand interactions on the in vivo… 
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Analysis of cytokine gene expression revealed that T cells from CD28-deficient mice failed to differentiate into Th2 cells in either the presence or absence of B7-dependent signals, and therefore did not recruit eosinophils to the airway.
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The effects of costimulatory molecule blockade on T helper effector cell function during the memory response were examined and the role of OX40L in Ag-specific CD4+ T cell IL-4 production following priming was examined.
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TLDR
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TLDR
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T-cell Subset Regulation in Atopy
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The understanding of the T-cell subset reciprocal interaction in atopy is discussed, including Th17 and Th9 cells, which control local tissue inflammation through upregulation of proinflammatory cytokines and chemokines.
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