Role of B cells in systemic lupus erythematosus and rheumatoid arthritis.

@article{MandikNayak2008RoleOB,
  title={Role of B cells in systemic lupus erythematosus and rheumatoid arthritis.},
  author={Laura Mandik-Nayak and Natalie Ridge and Michele Fields and Audrey Y. Park and Jan Erikson},
  journal={Current opinion in immunology},
  year={2008},
  volume={20 6},
  pages={639-45}
}
B cell tolerance to many self-proteins is actively maintained by either purging self-reactive B receptors through clonal deletion and receptor editing, or by functional silencing known as anergy. However, these processes are clearly incomplete as B cell driven autoimmune diseases still occur. The significance of B cells in two such diseases, rheumatoid arthritis and systemic lupus erythematosus, is highlighted by the ameliorative effects of B cell depletion. It remains to be determined, however… CONTINUE READING

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