Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice.

@article{Franco1995RoleOB,
  title={Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice.},
  author={Mayra Alvarez Franco and Harry B Greenberg},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={7800-6}
}
The immune mechanisms involved in clearance of and immunity to rotavirus infection are poorly understood. Although mice with severe combined immunodeficiency (SCID mice) become chronically infected, nude mice have been reported to clear rotavirus infection similarly to immunocompetent controls. To better characterize the role of cytotoxic T lymphocytes (CTLs) in clearance of and immunity to rotavirus infection, we infected naive or previously infected beta 2-microglobulin (beta 2m) knockout… CONTINUE READING
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