Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis

@article{Thurston2003RoleOA,
  title={Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis},
  author={Gavin Thurston},
  journal={Cell and Tissue Research},
  year={2003},
  volume={314},
  pages={61-68}
}
  • G. Thurston
  • Published 12 August 2003
  • Biology, Medicine
  • Cell and Tissue Research
This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been a major challenge. The evidence for the key role of the Angiopoietin/Tie system is discussed, and some of the other members of the system (Ang2, Tie1) are mentioned. A comparison… 
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TLDR
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TLDR
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TLDR
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  • H. Shimoda
  • Biology, Medicine
    Histochemistry and Cell Biology
  • 2008
TLDR
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TLDR
The role of tyrosine kinases in lymphatic biology and the potential use of inhibitors for anti-lymphangiogenic therapy are discussed.
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TLDR
Identification of key molecules involved in the regulation of angiogenesis may provide new possibilities for development of drugs suitable for inhibition ofAngiogenesis or its stimulation in various pathologies.
Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.
TLDR
It is found that angiopoietins can directly activate neutrophils through Tie2 signaling as well as modulate platelet-activating factor (PAF) synthesis and beta(2) integrin functional up-regulation, which might contribute to facilitate vascular remodeling and angiogenesis.
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References

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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
TLDR
It is shown that mice engineered to lack Angiopoietin-1 display angiogenic deficits reminiscent of those previously seen in mice lacking TIE2, demonstrating that AngiopOietIn-1 is a primary physiologic ligand for TIE1 and that it has critical in vivo angiogenesis actions that are distinct from VEGF and that are not reflected in the classic in vitro assays used to characterize VEGf.
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
TLDR
The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
TLDR
The identification of a secreted ligand for TIE2, termed Angiopoietin-1, is reported using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells.
Increased vascularization in mice overexpressing angiopoietin-1.
TLDR
It is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels, raising the possibility that angioietins can be used, alone or in combination with VEGF to promote therapeutic angiogenesis.
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
TLDR
A vascular growth factor whose primary role is in postnatal angiogenic remodeling is defined and it is demonstrated that members of the VEGF and Angiopoietin families collaborate during development of the lymphatic vasculature.
Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development.
TLDR
Vascularization of the mouse embryo is accomplished via the collaboration of two major cellular processes, namely angioblast differentiation and the directed migration of these cells through the embryo to segregate eventually into vascular cords.
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
TLDR
In vivo analyses of embryos deficient in Tie-2 showed that it is important in angiogen-esis, particularly for vascular network formation in endothelial cells, which contrasts with previous reports on Tie-1 function in vasculogenesis and/or endothelial cell survival.
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.
TLDR
The results demonstrate for the first time that Ang2 may have a direct role in stimulating Tie2 receptor signaling and inducing in vitro angiogenesis, and suggest that the physiological role of Ang2 is more complex than previously recognized.
Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn.
TLDR
This study examined the downstream signaling pathways involved in Ang2-mediated cellular responses by murine brain capillary cell line, IBE cells and found that c-Fyn was responsible for Ang-2- mediated tube formation.
Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
TLDR
Findings indicate that at high concentrations, Ang2, like Ang1, can be an apoptosis survival factor for endothelial cells through the activation of the Tie2 receptor, PI 3′-kinase and Akt, and thus may be a positive regulator of tumor angiogenesis.
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