Role of Allopurinol in Reducing Cerebral Hvpoxic-ischemic Injury during Reoxygenation-reperfusion

Abstract

Oxidation of hypoxanthine (HX) by xanthine oxidase (XO) has been hypothesized to be a potential source of oxygen-derived free radicles (O2−) during reoxygenation-perfusion of hypoxic-ischemic organs. Allopurinol (Al), a XO inhibitor, can reduce reperfusion injury. During hypoxia-ischemia, components of the mitochondrial electron-transport chain become… (More)
DOI: 10.1203/00006450-199402000-00150

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Cite this paper

@article{Wu1994RoleOA, title={Role of Allopurinol in Reducing Cerebral Hvpoxic-ischemic Injury during Reoxygenation-reperfusion}, author={Paul Wu and Won Sub Park and Frans F Jobsis-Vandervilict}, journal={Pediatric Research}, year={1994}, volume={35}, pages={279-279} }