Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  title={Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway},
  author={Masahiro Yamamoto and Shintaro Sato and Hiroaki Hemmi and Katsuaki Hoshino and Tsuneyasu Kaisho and Hideki Sanjo and Osamu Takeuchi and Masanaka Sugiyama and Masaru Okabe and Kiyoshi Takeda and Shizuo Akira},
  pages={640 - 643}
Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-β production. Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-β and activation of IRF-3. Furthermore, inflammatory cytokine production in… 

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