Role of Adaptor Proteins in Secretory Granule Biogenesis and Maturation

  title={Role of Adaptor Proteins in Secretory Granule Biogenesis and Maturation},
  author={Mathilde L. Bonnemaison and Betty A Eipper and Richard E Mains},
  booktitle={Front. Endocrinol.},
In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network and must undergo a maturation process to become responsive to secretagogues. The production of mature SGs requires concentrating newly synthesized soluble content proteins in granules whose membranes contain the appropriate integral membrane proteins. The mechanisms underlying the sorting of soluble and integral membrane proteins destined for… CONTINUE READING
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