Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations

Abstract

AIM To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. METHODS We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between AXL and TP53. These included HCT116… (More)
DOI: 10.3748/wjg.v23.i19.3440

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