Role of ATP in trauma-associated cytokine release and apoptosis by P2X7 ion channel stimulation.

@article{Schneider2006RoleOA,
  title={Role of ATP in trauma-associated cytokine release and apoptosis by P2X7 ion channel stimulation.},
  author={Elisabeth Marion Schneider and Katrin Vorlaender and Xueling Ma and Weidong Du and Manfred Weiss},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1090},
  pages={245-52}
}
Trauma causes immediate cytokine release and the systemic inflammatory response syndrome (SIRS), often preceding sepsis and septic shock. Mechanisms may involve P2X7 ion channel activation via adenosine 5'-triphosphate (ATP) released from surrounding tissue and platelets. A number of single nucleotide polymorphisms (SNPs) influence the nature and magnitude of P2X7-stimulated cytokine release and apoptosis. In whole blood and isolated mononuclear blood cells (PBMCs) of donors with wild-type and… CONTINUE READING