Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity.

@article{Vaziri2005RoleOA,
  title={Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity.},
  author={Nosratola D. Vaziri and Zhong-gao Xu and Ashkan Shahkarami and Kevin T. Huang and Bernardo Rodriguez-Iturbe and Rama Natarajan},
  journal={Kidney international},
  year={2005},
  volume={68 6},
  pages={2787-93}
}
BACKGROUND Metabolic syndrome has emerged as the major cause of atherosclerosis. The associated atherosclerosis is accompanied by and, in part, due to inflammation. In an attempt to explore the molecular sources of vascular inflammation and possible involvement of renin-angiotensin system, we studied obese Zucker rats, which exhibit all features of metabolic syndrome. METHODS Seven-week-old male obese Zucker rats were randomized to losartan-treated (100 mg/L drinking H2O) and untreated groups… CONTINUE READING

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