Role of APP in neuronal function


Background Genetic and biochemical studies establish a central role of the amyloid precursor protein (APP) in Alzheimer’s disease (AD): Genetic mutations and gene amplification of APP are linked to early onset of familial Alzheimer’s disease (FAD); APP processing generates b-amyloid (Ab) peptides, which are the principal components of the amyloid pathology… (More)
DOI: 10.1186/1750-1326-8-S1-O4