Role of APOBEC3 in Genetic Diversity among Endogenous Murine Leukemia Viruses

@article{Jern2007RoleOA,
  title={Role of APOBEC3 in Genetic Diversity among Endogenous Murine Leukemia Viruses},
  author={P. Jern and J. Stoye and J. Coffin},
  journal={PLoS Genetics},
  year={2007},
  volume={3}
}
The ability of human and murine APOBECs (specifically, APOBEC3) to inhibit infecting retroviruses and retrotransposition of some mobile elements is becoming established. Less clear is the effect that they have had on the establishment of the endogenous proviruses resident in the human and mouse genomes. We used the mouse genome sequence to study diversity and genetic traits of nonecotropic murine leukemia viruses (polytropic [Pmv], modified polytropic [Mpmv], and xenotropic [Xmv] subgroups… Expand
Studies on the Restriction of Murine Leukemia Viruses by Mouse APOBEC3
TLDR
The Gag protein does not seem to control the sensitivity of MLVs to mA3, and it is found that MLVs inactivated bymA3 do not synthesize viral DNA upon infection; thus mA 3 restriction of MLV occurs before or at reverse transcription. Expand
Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms
TLDR
These results indicate that the mechanisms of APOBEC3 restriction of KoRV by hA3G and mA3 differ (deamination dependent vs. independent) and glyco-gag does not play a role in the restriction. Expand
Footprint of APOBEC3 on the Genome of Human Retroelements
TLDR
Analysis of the mutation signatures of these proteins on large populations of long interspersed nuclear element (LINE), short intersp swapped nuclear element(SINE), and endogenous retrovirus (ERV) families in the human genome to infer possible evolutionary pressure and/or hypermutation events is analyzed. Expand
Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice
TLDR
The data reveal that hA3G can potently restrict active ERV in vivo and suggest that expansion of the APOBEC3 locus in primates may have helped to provide for the continued restraint of ERv in the human genome. Expand
Hypermutation of an Ancient Human Retrovirus by APOBEC3G
TLDR
It is shown that several human APOBEC3 proteins are intrinsically capable of mutating and inhibiting infection by HERV-K(HML-2) in cell culture, and striking evidence that two HERv-K proviruses that are fixed in the modern human genome were subjected to hypermutation by a cytidine deaminase. Expand
Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range
TLDR
Genome-wide analysis shows that nonecotropic replacements in the progenitor ecotropic MLV genome are more extensive than previously appreciated, covering 100% of the genome; contributions from xenotropic and polytropic ERVs differentially alter the regions responsible for receptor determination or subject to APOBEC3 and Fv1 restriction. Expand
Title Human and murine APOBEC 3 s restrict replication of koala retrovirus by different mechanisms
Background: Koala retrovirus (KoRV) is an endogenous and exogenous retrovirus of koalas that may cause lymphoma. As for many other gammaretroviruses, the KoRV genome can potentially encode anExpand
Interactions of Murine APOBEC3 and Human APOBEC3G with Murine Leukemia Viruses
TLDR
It is found that mA3 inactivates MLV but is significantly less effective against MLV than is hA3G, and MLV has apparently evolved to partially resist the antiviral effects of mA 3 and to totally resist the ability ofmA3 to induce G-to-A mutation in viral DNA. Expand
Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo
TLDR
It is shown that polymorphisms at the mouse APOBEC3 locus indeed influence F-MuLV replication and pathogenesis: the APOBec3 alleles of F- MuLV-resistant C57BL/6 and -susceptible BALB/c mice differ in their sequences and expression levels in the hematopoietic tissues and in their abilities to restrict F-muLV replication both in vitro and in vivo. Expand
Interactions between APOBEC3 and murine retroviruses: Mechanisms of restriction and drug resistance
TLDR
It is shown that endogenous APOBEC3 protein is efficiently packaged into viral cores, and this protein maintains catalytic activity against artificial substrates, and can be targeted through virion-packaged or cell-associated protein. Expand
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