Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils.

@article{RatajczakWrona2013RoleOA,
  title={Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils.},
  author={Wioletta Ratajczak-Wrona and Ewa Jablonska and Marzena Garley and Jakub Jablonski and Piotr M Radziwon and Agnieszka Iwaniuk},
  journal={Journal of immunotoxicology},
  year={2013},
  volume={10 1},
  pages={32-9}
}
The aim of the study was to assess the activity of AP-1 family proteins, e.g. Fra-1, Fra-2, JunB, JunD, and FosB, engaged in the regulation of inducible nitric oxide synthase (iNOS) expression and the production of NO by neutrophils (PMN) exposed to N-nitrosodimethylamine (NDMA) xenobiotic. Isolated human PMN were incubated in the presence of NDMA. iNOS mRNA expression was then analyzed using Northern blot and the expression of other proteins in the cytoplasmic and nuclear fractions were… CONTINUE READING