Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

  title={Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity},
  author={Christian L{\"u}scher and Houhui Xia and Eric C. Beattie and Reed C. Carroll and Mark Zastrow and Robert C Malenka and Roger A Nicoll},
Compounds known to disrupt exocytosis or endocytosis were introduced into CA1 pyramidal cells while monitoring excitatory postsynaptic currents (EPSCs). Disrupting exocytosis or the interaction of GluR2 with NSF caused a gradual reduction in the AMPAR EPSC, while inhibition of endocytosis caused a gradual increase in the AMPAR EPSC. These manipulations had no effect on the NMDAR EPSC but prevented the subsequent induction of LTD. These results suggest that AMPARs, but not NMDARs, cycle into and… CONTINUE READING
Highly Influential
This paper has highly influenced 59 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 353 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

Different modes of expression of AMPA and NMDANeurobiol . 7 , 368 – 373 . receptors in hippocampal synapses

  • Y. Takumi, V. Ramı́rez-León, P. Laake, E. Rinvik, O. P. Ottersen
  • Nat . Neurosci .
  • 1999
Highly Influential
15 Excerpts

272 , 20564 – 20571 . tion

  • I. Song, S. Kamboj, +7 authors J. H. Morrison
  • Science
  • 1998
Highly Influential
4 Excerpts

Rapid , activationinduced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons

  • M. trow
  • 1999

Similar Papers

Loading similar papers…