Role of AMP-activated protein kinase in mechanism of metformin action.

@article{Zhou2001RoleOA,
  title={Role of AMP-activated protein kinase in mechanism of metformin action.},
  author={G. Zhou and R. Myers and Y. Li and Y. Chen and X. Shen and J. Fenyk-Melody and M. Wu and J. Ventre and T. Doebber and N. Fujii and N. Musi and M. Hirshman and L. Goodyear and D. Moller},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 8},
  pages={
          1167-74
        }
}
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects on circulating lipids have been linked to reduced fatty liver. AMP-activated protein kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism. Here we report that metformin activates AMPK in hepatocytes; as a result, acetyl… Expand
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