Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation.

@article{Bijland2013RoleOA,
  title={Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation.},
  author={Silvia Bijland and Sarah J. Mancini and Ian P. Salt},
  journal={Clinical science},
  year={2013},
  volume={124 8},
  pages={
          491-507
        }
}
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while stimulating catabolic ATP-generating pathways. This has led to considerable interest in AMPK as a therapeutic target for the metabolic dysfunction observed in obesity and insulin resistance. The role of AMPK in skeletal muscle and the liver has been… 
View on PubMed
eprints.gla.ac.uk
216 Citations
Highly Influential Citations
10
Background Citations
76
Results Citations
3

216 Citations

Citation Type

Citation Type

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis
TLDR
Data indicate that increased expression of AMPKβ2 is an important feature of efficient adipogenesis, and small molecules that selectively influence AMPK heterotrimers containing specific AM PKβ subunit isoforms have been developed, including MT47-100, which selectively inhibits complexes containing AMPK β2.
Regulation of nutrient uptake by AMP-activated protein kinase.
The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue
TLDR
The role of AMPK is discussed, emphasizing its role in the energy expenditure of brown/beige adipose tissue and browning of WAT, which can provide new insights into obesity research and treatment.
Salt-inducible kinases in adipose tissue
TLDR
The data suggest that insulin resistance might be a causal factor underlying the downregulation of SIK2 in human adipose tissue, and might provide an attractive therapeutic target for the treatment of metabolic diseases in the future.
Vascular AMPK as an attractive target in the treatment of vascular complications of obesity.
AMP‐activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events
TLDR
This study suggests that AMPK inhibits cancer cell growth and tumorigenesis via regulation of mitochondria‐mediated metabolism.
Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity
TLDR
It is shown that PKD1 promotes lipogenesis and suppresses mitochondrial fragmentation, biogenesis, respiration, and energy dissipation in an AMP‐activated protein kinase (AMPK)‐dependent manner, and mice lacking PKD0 are resistant to diet‐induced obesity due to elevated energy expenditure.
Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.
TLDR
The most recent advances in the understanding of the mechanism(s) of action) of the current portfolio of AMPK activators, including plant-derived natural compounds and newly discovered small-molecule agonists directly targeting various AMPK subunits are reviewed.
The role of protein kinase D (PKD) in intracellular nutrient sensing and regulation of adaptive responses to the obese environment
TLDR
The emerging evidence suggests that PKD plays an important role in regulating the adaptive response to the obese environment and is highlighted as a novel nutrient sensor.
Effects of AMPK activation on lipolysis in primary rat adipocytes: studies at different glucose concentrations
TLDR
Results indicate that short-term activation of AMPK by AICAR in the rat adipocytes inhibits lipolysis, due to changes in the final, followed by protein kinase A (PKA), steps of the lipolytic cascade and improves intracellular energy status.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 210 REFERENCES
Functions of AMP‐activated protein kinase in adipose tissue
TLDR
Since fatty acids have a key role in insulin resistance, especially in muscles, activating AMPK in adipose tissue might be found to be beneficial in insulin‐resistant states, particularly as AMPK activation also reduces cytokine secretion in adipocytes.
AMP-activated protein kinase and metabolic control.
TLDR
It is now recognized that pharmacological activation of AMPK improves blood glucose homeostasis, lipid profile, and blood pressure in insulin-resistant rodents, and the logic underlying the concept of targeting the AMPK pathway for the treatment of metabolic syndrome and type 2 diabetes is highlighted.
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.
TLDR
The results suggest that the increase in lipid storage in adipose tissue in AMPKalpha2 KO mice may have protected these mice from further impairment of glucose homeostasis that normally accompanies high-fat feeding.
AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity
TLDR
Data show that AMPKα1 protects mice from diet-induced obesity and insulin resistance, demonstrating that AM PKα1 is a promising therapeutic target in the treatment of the metabolic syndrome.
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
TLDR
It is shown that leptin selectively stimulates phosphorylation and activation of the α2 catalytic subunit of AMPK (α2 AMPK) in skeletal muscle, thus establishing a previously unknown signalling pathway for leptin, and identifying AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
TLDR
It is shown that phosphorylation and activation of the 5′-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length Ad in skeletal muscle and only with full- lengths Ad in the liver, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK.
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans.
Chronic Hexosamine Flux Stimulates Fatty Acid Oxidation by Activating AMP-activated Protein Kinase in Adipocytes*
TLDR
Chronic high hexosamine flux stimulates fatty acid oxidation by activating AMPK in adipocytes, in part through O-linked glycosylation, demonstrating that AMPK is regulated by the HBP.
Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo
TLDR
Statins can rapidly activate AMPK via increased Thr-172 phosphorylation in vitro and in vivo, which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system.
Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway.
TLDR
Results indicate that CaMKKβ/AMPK signaling is an important molecular component in regulating lipid metabolism in adipocytes responding to glucagon and could be a therapeutic target for the dysregulation of energy storage.
...
1
2
3
4
5
...