Role of ALK activation in the development and maintenance of the neoplastic phenotype in neuroblastoma.

@article{Regairaz2009RoleOA,
  title={Role of ALK activation in the development and maintenance of the neoplastic phenotype in neuroblastoma.},
  author={M. Regairaz and F. Munier and H. Sartelet and V. Marty and M. Castaing and S. Michiels and M. Fabr{\`e} and J. Roesel and G. Vassal},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 15_suppl},
  pages={10008}
}
  • M. Regairaz, F. Munier, +6 authors G. Vassal
  • Published 2009
  • Biology, Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
10008 Background: Activating mutations of the Anaplastic Lymphoma Kinase (ALK) receptor could be responsible for most familial neuroblastoma cases and for up to 15% of somatic cases. The objective of the present study was to further investigate the role of ALK activation in neuroblastoma. METHODS Tissue microarrays were constructed containing 101 primary tumors and 56 paired normal tissues. Sections were immunostained with anti-ALK or anti-P-ALK antibodies, and with antibodies directed… Expand