Role of ADP in platelet aggregation at high shear: studies in a patient with congenital defect of platelet responses to ADP.

@article{Cattaneo1994RoleOA,
  title={Role of ADP in platelet aggregation at high shear: studies in a patient with congenital defect of platelet responses to ADP.},
  author={Marco Cattaneo and Maddalena Loredana Zighetti and Rossana Lombardi and Pier Mannuccio Mannucci},
  journal={British journal of haematology},
  year={1994},
  volume={88 4},
  pages={826-9}
}
The in vitro measurement of platelet aggregation (PA) at the high shear levels that can be found in the microcirculation may provide useful informations on primary haemostasis, which is usually explored in vivo with the skin bleeding time (BT). PA at high shear requires von Willebrand factor (vWf) and the platelet glycoprotein (GP) complexes Ib/IX/V and IIb/IIIa; controversial results have been reported on its requirement of released adenosine diphosphate (ADP). Due to its dependence on vWf, PA… CONTINUE READING
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