Role of A1 adenosine receptors in regulation of vascular tone.

@article{Tawfik2005RoleOA,
  title={Role of A1 adenosine receptors in regulation of vascular tone.},
  author={Huda E. Tawfik and Jurgen Schnermann and Peter J. Oldenburg and Syed Jamal Mustafa},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 3},
  pages={
          H1411-6
        }
}
The vascular response to adenosine and its analogs is mediated by four adenosine receptors (ARs), namely, A(1), A(2A), A(2B), and A(3). A(2A)ARs and/or A(2B)ARs are involved in adenosine-mediated vascular relaxation of coronary and aortic beds. However, the role of A(1)ARs in the regulation of vascular tone is less well substantiated. The aim of this study was to determine the role of A(1)ARs in adenosine-mediated regulation of vascular tone. A(1)AR-knockout [A(1)AR((-/-))] mice and available… 

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