Role of 53 BP 1 oligomerization in regulating double-strand break repair

@inproceedings{Lottersbergera2014RoleO5,
  title={Role of 53 BP 1 oligomerization in regulating double-strand break repair},
  author={Francisca Lottersbergera and Anne Bothmerb and Davide F. Robbianib and Michel C. Nussenzweigb and Titia de Langea},
  year={2014}
}
  • Francisca Lottersbergera, Anne Bothmerb, +2 authors Titia de Langea
  • Published 2014
Tumor suppressor p53-binding protein 1 (53BP1) regulates the repair of dysfunctional telomeres lacking the shelterin protein TRF2 by promoting their mobility, their nonhomologous endjoining (NHEJ), and, as we show here, by blocking 5′ resection by CtIP. We report that these functions of 53BP1 required its N-terminal ATM/ATR target sites and its association with H4K20diMe, but not the BRCT domain, the GAR domain, or the binding of 53BP1 to dynein. A mutant lacking the oligomerization domain… CONTINUE READING