Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.

  title={Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.},
  author={Anna Adamek and Susanne Jung and Charlotte Dienesch and Martin Laser and Georg Ertl and Johann Bauersachs and Stefan Frantz},
  journal={European journal of pharmacology},
  volume={571 1},
Myocardial ischemia induces 5-lipoxygenase (LOX) translocation and leukotriene production in the heart. Leukotrienes increase inflammatory responses and could thereby aggravate ischemic injury. However, the role of lipoxygenase and leukotrienes in cardiac ischemia/reperfusion damage has not been well defined. Therefore, we tested the effect of ischemia reperfusion in mice with targeted deletion of 5-lipoxygenase, the enzyme converting arachidonic acid in leukotrienes. 5-LOX deficient (KO) and… CONTINUE READING


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