Role of 5-HT5A receptors in the consolidation of memory

@article{Gonzalez2013RoleO5,
  title={Role of 5-HT5A receptors in the consolidation of memory},
  author={R. Gonzalez and Karla Ch{\'a}vez-Pascacio and Alfredo Meneses},
  journal={Behavioural Brain Research},
  year={2013},
  volume={252},
  pages={246-251}
}
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43 Citations
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43 Citations

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The results demonstrated that the synergistic effect between both hippocampal 5-HT4 receptor agonist and antagonist with impairment of memory acquisition induced by harmaline, indicating a modulatory effect for hippocampusal 5HT4 receptors on Harmaline induced amnesia.
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Findings showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol.
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The blockade of the serotoninergic receptors 5-HT5A, 5-HT6 and 5-HT7 in the basolateral amygdala, but not in the hippocampus facilitate the extinction of fear memory
Effects of 5-HT5A receptor blockade on amnesia or forgetting
Interaction between harmane, a class of β-carboline alkaloids, and the CA1 serotonergic system in modulation of memory acquisition
Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative
  • A. Meneses
  • Biology, Psychology
    Reviews in the neurosciences
  • 2014
TLDR
Evidence suggests that both 5-HT7 receptor agonists and antagonists might have promnesic and anti-amnesic effects, which seem to be dependent on the basal level of performance, i.e., normal or impaired.
Involvement of the serotonergic system of the ventral hippocampus (CA3) on amnesia induced by ACPA in mice
GR-127935-sensitive Mechanism Mediating Hypotension in Anesthetized Rats: Are 5-HT5B Receptors Involved?
TLDR
It is suggested that the GR-127935-sensitive mechanism mediating hypotension in rats is unrelated to 5-HT1B, 5- HT1D, 3-HT5A, 4-HT6, and5-HT7 receptors; this mechanism, however, resembles putative 5-ht5B receptors.
Serotonergic 5-HT7 receptors and cognition
TLDR
The aim of this review is to clarify the behavioral role of the recently discovered 5-HT7 type receptor and highlight its involvement in the cognitive functions, with particular attention to the modulation of learning and memory processes, thus providing a basis to obtain new therapeutic agents and strategies for the treatment of cognitive disorders.
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