Role of 5-HT5A receptors in the consolidation of memory

  title={Role of 5-HT5A receptors in the consolidation of memory},
  author={R. Gonzalez and Karla Ch{\'a}vez-Pascacio and A. Meneses},
  journal={Behavioural Brain Research},
  • R. Gonzalez, Karla Chávez-Pascacio, A. Meneses
  • Published 2013
  • Psychology, Medicine
  • Behavioural Brain Research
  • 5-HT5 receptor occurs in brain areas implicated in learning and memory. Hence, the effects (0.01-3.0 mg/kg) of SB-6995516 (a 5-HT5A receptor antagonist) in the associative learning task of autoshaping were studied. The results showed that post-training injection of SB-699551 decreased conditioned responses (CR) during short-term (STM; 1.5h; at 0.1mg/kg) and long-term memory (LTM; 24 h; at 3.0 mg/kg) relative to the vehicle animals. Moreover, considering that there are no selective 5-HT5A… CONTINUE READING
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