Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat

@article{McLean2009RoleO5,
  title={Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat},
  author={Samantha L. McLean and Marie L. Woolley and Dave W. Thomas and Joanna C. Neill},
  journal={Psychopharmacology},
  year={2009},
  volume={206},
  pages={403-414}
}
5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. The aim of this study was to investigate the involvement of 5-HT receptor mechanisms in sub-chronic phencyclidine (PCP)-induced reversal learning deficits in female rats, a task of relevance to schizophrenia. Adult female hooded Lister rats were trained to perform an operant reversal learning task and then received sub-chronic PCP (2 mg/kg) or vehicle intraperitoneally (i.p.) twice daily for 7… CONTINUE READING

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