Role of 5α-reductase inhibitors in benign prostatic diseases


Testosterone is the most abundant androgen in serum. Intracellularly, testosterone is converted to dihydrotestosterone, the preferred ligand for androgen receptor transactivation, by the enzyme 5α-reductase. Three 5α-reductase isozymes have been discovered and they are expressed ubiquitously in human tissues. Testosterone and dihydrotestosterone have… (More)
DOI: 10.1038/pcan.2012.1


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@article{Azzouni2012RoleO5, title={Role of 5α-reductase inhibitors in benign prostatic diseases}, author={Faris S Azzouni and James L. Mohler}, journal={Prostate Cancer and Prostatic Diseases}, year={2012}, volume={15}, pages={222-230} }