Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function.

@article{Hubbard1995RoleO5,
  title={Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function.},
  author={Neil E. Hubbard and Kent L. Erickson},
  journal={Cellular immunology},
  year={1995},
  volume={160 1},
  pages={115-22}
}
Metabolites of arachidonic acid have been shown to be potent biological modulators of macrophage function. While the role of cyclooxygenase metabolites of arachidonic acid have been well studied, metabolites of lipoxygenase have not. In this report, we evaluate the role that select 5'-lipoxygenase (5'-LO) products may play in macrophage activation for select tumoricidal functions. When thioglycollate-elicited macrophages were treated with inhibitors of 5'-LO during activation, cytolytic… CONTINUE READING

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