Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

@article{Weisov2011RoleO5,
  title={Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.},
  author={Petronela Weisov{\'a} and David Rinc{\'o}n D{\'a}vila and Liam P. Tuffy and Manus W. Ward and Caoimh{\'i}n G. Concannon and Jochen H. M. Prehn},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 10},
  pages={
          1863-76
        }
}
5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate, in particular cell cycle progression and apoptosis activation. Here, we describe the diverse mechanisms of AMPK activation and the role of AMPK in the regulation of cellular… CONTINUE READING

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