Role of 3beta-hydroxysteroid-delta 24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells.

@article{McGrath2009RoleO3,
  title={Role of 3beta-hydroxysteroid-delta 24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells.},
  author={Kristine C. Y. McGrath and Xin Hua Li and Rajesh Puranik and Eleanore C Liong and Joanne T M Tan and Veronica Dy and B A DiBartolo and Philip John Barter and Kirsten Rye and Alison Kay Heather},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 6},
  pages={
          877-82
        }
}
OBJECTIVE The purpose of this study was to investigate the ability of high-density lipoproteins (HDLs) to upregulate genes with the potential to protect against inflammation in endothelial cells. METHODS AND RESULTS Human coronary artery endothelial cells (HCAECs) were exposed to reconstituted HDLs (rHDLs) for 16 hours before being activated with tumor necrosis factor-alpha (TNF-alpha) for 5 hours. rHDLs decreased vascular cell adhesion molecule-1 (VCAM-1) promoter activity by 75% (P<0.05… CONTINUE READING
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