Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease.

@article{ParadaBustamante2015RoleO2,
  title={Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease.},
  author={Alexis Parada-Bustamante and Cecilia Valencia and Patricia Reuqu{\'e}n and Patricia D{\'i}az and Ramiro Rincion-Rodriguez and Pedro A. Orihuela},
  journal={Mini reviews in medicinal chemistry},
  year={2015},
  volume={15 5},
  pages={
          427-38
        }
}
Estradiol (E2) is a steroid hormone whose physiological actions are mainly mediated by its interaction with intracellular estrogen receptors (ER) leading to modification on the mRNA and protein synthesis in its target cells. However, estrogens can also activate several intracellular signal transduction cascades by non-genomic mechanisms. Estrogens must be inactivated and removed from blood through its conversion to soluble compounds with an apparent low estrogenic activity and decreased… 

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