Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension

@article{Zhu2012RoleO1,
  title={Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension},
  author={Daling Zhu and Yajuan Ran},
  journal={The Journal of Physiological Sciences},
  year={2012},
  volume={62},
  pages={163-172}
}
  • Daling Zhu, Yajuan Ran
  • Published 14 February 2012
  • Medicine, Biology
  • The Journal of Physiological Sciences
Pulmonary arterial hypertension (PAH) is a rare disease with a complex aetiology characterized by elevated pulmonary artery resistance, which leads to right heart ventricular afterload and ultimately progressing to right ventricular failure and often death. In addition to other factors, metabolites of arachidonic acid cascade play an important role in the pulmonary vasculature, and disruption of signaling pathways of arachidonic acid plays a central role in the pathogenesis of PAH. 15… 
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TLDR
Results show that 15-HETE mediates hypoxia-induced pulmonary vascular remodeling and stimulates angiogenesis via the Rho-kinase pathway.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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