Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury.

@article{Mochizuki2005RoleO1,
  title={Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury.},
  author={Mie Mochizuki and Yukio Ishii and Ken Itoh and Takashi Iizuka and Yuko Morishima and Toru Kimura and Takumi Kiwamoto and Yosuke Matsuno and Ahamed E. Hegab and Akihiro Nomura and Tohru Sakamoto and Koji Uchida and Masayuki Yamamoto and Kiyohisa Sekizawa},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={171 11},
  pages={
          1260-6
        }
}
RATIONALE Acute lung injury (ALI) is a disease process that is characterized by diffuse inflammation in the lung parenchyma. Recent studies demonstrated that cyclooxygenase-2 (COX-2) induced at the late phase of inflammation aids in the resolution of inflammation by generating 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2). Transcription factor Nrf2 is activated by electrophiles and exerts antiinflammatory effects by inducing the gene expression of antioxidant and detoxification enzymes… CONTINUE READING
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