Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model

@article{Natarajan2002RoleO1,
  title={Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model},
  author={R. Natarajan and R. Gerrity and J. Gu and L. Lanting and L. Thomas and J. Nadler},
  journal={Diabetologia},
  year={2002},
  volume={45},
  pages={125-133}
}
  • R. Natarajan, R. Gerrity, +3 authors J. Nadler
  • Published 2002
  • Medicine, Biology
  • Diabetologia
  • Abstract.Aims/hypothesis: We previously showed that vascular smooth muscle cells and endothelial cells cultured under high glucose conditions produced more 12(S)-hydroxyeicosatetraenoic acid (12-HETE), the 12-lipoxygenase (12-LO) product of arachidonate metabolism, relative to normal glucose. Because the lipoxygenase (LO) pathway has been associated with oxidant stress and the pathogenesis of atherosclerosis, we now examined 12-LO activation in vivo in a pig model of diabetes-induced… CONTINUE READING
    Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes.
    • 108
    • PDF
    Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells.
    • 80
    • PDF