Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.

  title={Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.},
  author={Yeshao Wen and Jiali Gu and George E. Vandenhoff and Xiaoping Liu and Jerry L Nadler},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={294 4},
Monocyte chemoattractant protein (MCP)-1 plays a key role in atherosclerosis and inflammation associated with visceral adiposity by inducing mononuclear cell migration. Evidence shows that mouse peritoneal macrophages (MPM) express a 12-lipoxygenase (12/15-LO) that has been clearly linked to accelerated atherosclerosis in mouse models and increased monocyte endothelial interactions in both rodent and human cells. However, the role of 12/15-LO products in regulating MCP-1 expression in… CONTINUE READING


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