Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.


Monocyte chemoattractant protein (MCP)-1 plays a key role in atherosclerosis and inflammation associated with visceral adiposity by inducing mononuclear cell migration. Evidence shows that mouse peritoneal macrophages (MPM) express a 12-lipoxygenase (12/15-LO) that has been clearly linked to accelerated atherosclerosis in mouse models and increased monocyte… (More)
DOI: 10.1152/ajpheart.00260.2007


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