Role of 11βHSD type 2 enzyme activity in essential hypertension and children with chronic kidney disease (CKD).

@article{Mongia2012RoleO1,
  title={Role of 11βHSD type 2 enzyme activity in essential hypertension and children with chronic kidney disease (CKD).},
  author={Anil Mongia and Risa Vecker and Minu George and Anita Pandey and Hanan K. Tawadrous and Morris J. Schoeneman and Ozgul Muneyyirci-Delale and Vijaya L Nacharaju and Svetlana B Ten and Amrit P S Bhangoo},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 10},
  pages={3622-9}
}
BACKGROUND The mineralocorticoid receptor is protected from excess of glucocorticoids by conversion of active cortisol to inactive cortisone by enzyme 11β-hydroxysteroid dehydrogenase type 2 present in the kidney. The metabolites of cortisol and cortisone are excreted in the urine as tetrahydrocortisol (5αTHF+5βTHF) and tetrahydrocortisone (THE), respectively. HYPOTHESIS Patients with chronic kidney disease (CKD) and essential hypertension have a functional defect in their ability to convert… CONTINUE READING
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