Role of κ-opioid receptor in hypoxic pulmonary artery hypertension and its underlying mechanism.

Abstract

The objective of this study were to determine the mechanism of action and role of the κ-opioid receptor (κ-OR) on hypoxic pulmonary artery hypertension (HPH) in the rat and its underlying mechanisms. The effect of U50,488H, a selective κ-OR agonist, on the proliferation of pulmonary arterial smooth muscle cells (PASMCs) under hypoxic conditions were… (More)
DOI: 10.1097/MJT.0b013e318249a08c

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