Role of [corrected] nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner.

@article{Matsumoto1999RoleO,
  title={Role of [corrected] nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner.},
  author={Naoyuki Matsumoto and T Hanakawa and Shinichiro Maki and Ann M. Graybiel and Minoru Kimura},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 2},
  pages={
          978-98
        }
}
Neurons in the primate striatum and the substantia nigra pars compacta change their firing patterns during sensory-motor learning. To study the consequences of nigrostriatal dopamine depletion for learning and memory of motor sequences, we used a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to deplete dopamine unilaterally in the striatum of macaque monkeys either before or after training them on sequential push-button motor tasks. We compared the monkeys' performance with… 

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