Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis.

@article{Sugisaki2013RoleO,
  title={Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis.},
  author={Kentaro Sugisaki and Tomoko Hanawa and Hideo Yonezawa and Takako Osaki and Toshiyuki Fukutomi and Hayato Kawakami and Tomoko Yamamoto and Shigeru Kamiya},
  journal={Microbiology},
  year={2013},
  volume={159 Pt 7},
  pages={
          1379-89
        }
}
Bordetella pertussis, the causative agent of whooping cough, is highly adapted to cause human infection. The production of virulence factors, such as adhesins and toxins, is just part of an array of mechanisms by which B. pertussis causes infection. The stringent response is a global bacterial response to nutritional limitation that is mediated by the accumulation of cellular ppGpp and pppGpp [termed together as (p)ppGpp]. Here, we demonstrate that production of (p)ppGpp was controlled by RelA… CONTINUE READING

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