Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site.

@article{Shimomura2006RoleIT,
  title={Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site.},
  author={Masaru Shimomura and Maiko Yokota and Makoto Ihara and Miki Akamatsu and David B Sattelle and Kazuhiko Matsuda},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 4},
  pages={1255-63}
}
The insecticide imidacloprid and structurally related neonicotinoids act selectively on insect nicotinic acetylcholine receptors (nAChRs). To investigate the mechanism of neonicotinoid selectivity, we have examined the effects of mutations to basic amino acid residues in loop D of the nAChR acetylcholine (ACh) binding site on the interactions with imidacloprid. The receptors investigated are the recombinant chicken alpha4beta2 nAChR and Drosophila melanogaster Dalpha2/chicken beta2 hybrid nAChR… CONTINUE READING