Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.

@article{Rubino2008RoleIA,
  title={Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex.},
  author={T Rubino and Natalia Realini and Chiara Castiglioni and Cinzia Guidali and Daniela Vigan{\`o} and Emanuela Marras and Stefania Petrosino and Gianpaolo Perletti and Mauro Maccarrone and Vincenzo Di Marzo and Daniela Parolaro},
  journal={Cerebral cortex},
  year={2008},
  volume={18 6},
  pages={1292-301}
}
In the present study we explored with a multidisciplinary approach, the role of anandamide (AEA) in the modulation of anxiety behavior at the level of the prefrontal cortex (PFC). Low doses of the metabolically stable AEA analog, methanandamide, microinjected into the PFC, produced an anxiolytic-like response in rats, whereas higher doses induced anxiety-like behaviors. Pretreatment with the selective antagonist of CB1 or TRPV1 receptors (AM251 and capsazepine, respectively) suggested that the… CONTINUE READING
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