Role in Cardiovascular Biology and Disease

  title={Role in Cardiovascular Biology and Disease},
  author={Dan Sorescu},
Reactive oxygen species have emerged as important molecules in cardiovascular function. Recent work has shown that NAD(P)H oxidases are major sources of superoxide in vascular cells and myocytes. The biochemical characterization, activation paradigms, structure, and function of this enzyme are now partly understood. Vascular NAD(P)H oxidases share some, but not all, characteristics of the neutrophil enzyme. In response to growth factors and cytokines, they produce superoxide, which is… CONTINUE READING
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Convergence of redox-sensitive and mitogen activated protein kinase signaling pathways in TNF a-mediated MCP-1 induction in vascular smooth muscle cells

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