Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.

@article{Safi2004RoleFT,
  title={Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.},
  author={Alexias Safi and Marie Vandromme and Sabine Caussanel and Laure Valdacci and Dominique Baas and Marc Vidal and Gilbert Brun and Laurent Schaeffer and Evelyne Goillot},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 3},
  pages={1245-55}
}
In this work, we report the implication of the pleckstrin homology (PH) domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase (PI3-K)-regulated muscle differentiation. CKIP-1 is upregulated during muscle differentiation in C2C12 cells. We show that CKIP-1 binds to phosphatidylinositol 3-phosphate through its PH domain and localizes to the plasma membrane in a PI3-K-dependent manner. Activation of PI3-K by insulin or expression of an active form of PI3-K p110 induces a rapid… CONTINUE READING

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Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
Upon induction of differentiation in low - serum medium , CKIP-1 overexpression in C2C12 myoblasts first promotes proliferation and then stimulates the expression of myogenin and cell fusion in a manner reminiscent of the dual positive effect of insulin - like growth factors on muscle cells .
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