Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.

@article{LucioEterovic2010RoleFT,
  title={Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.},
  author={Agda Karina Brodoloni Lucio-Eterovic and Melissa M. Singh and Jeffrey E Gardner and Chendhore S. Veerappan and Judd C. Rice and Phillip B. Carpenter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 39},
  pages={16952-7}
}
The NSD (nuclear receptor-binding SET domain protein) family encodes methyltransferases that are important in multiple aspects of development and disease. Perturbations in NSD family members can lead to Sotos syndrome and Wolf-Hirschhorn syndrome as well as cancers such as acute myeloid leukemia. Previous studies have implicated NSD1 (KMT3B) in transcription and methylation of histone H3 at lysine 36 (H3-K36), but its molecular mechanism in these processes remains largely unknown. Here we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…