Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses.

@article{Liu2015RoleFT,
  title={Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses.},
  author={Yang Liu and Mengle Shao and Yan Yan Wu and Cheng Hua Yan and Shan Jiang and Jingnan Liu and Jianli Dai and Liu Yang and Jia Li and Weiping Jia and Liangyou Rui and Yong Liu},
  journal={Journal of hepatology},
  year={2015},
  volume={62 3},
  pages={590-8}
}
BACKGROUND & AIMS As the main detoxifying organ of the body, the liver possesses a remarkable ability to regenerate after toxic injury, tissue resection or viral infection. A growing number of cellular signaling pathways have been implicated in orchestrating the process of liver regeneration. Here we investigated the role of inositol-requiring enzyme-1α (IRE1α), a key signal transducer of the unfolded protein response (UPR), in liver regeneration. METHODS Using mice with hepatocyte-specific… CONTINUE READING
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